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Pseudocatalase Information


From
Skin & Allergy News
Patented Cream Can Hold Vitiligo at Bay
Author: Mike Bykowski, Staff Writer
Skin & Allergy News 29(5):32, 1998. 1998 International Medical News Group.


SHORT HILLS, N.J. -- A new cream can clear almost all traces of vitiligo from the hands and faces of over half of the patients with the disorder, Dr. Karin U. Schallreuter said at a conference on cosmeceuticals sponsored by International Business Communications.

Dr. Schallreuter, professor of clinical and experimental dermatology at the University of Bradford in West Yorkshire, England, and her colleagues have developed a patented cream, pseudocatalase, which in combination with calcium has achieved very high success rates in treating vitiligo.

The pseudocatalase cream only works in about 60% of Vitiligo patients, but in these patients, a treatment regimen combining pseudocatalase and calcium is up to 95% effective in clearing affected hands and faces, Dr. Schallreuter said.

She has treated 220 patients with this regimen. Pseudocatalase is not yet available. (webmaster's note: at this time, Pseudocatalase IS available in Europe and the United States, and more patients have been treated with it.)

It remains unclear which patients are candidates for pseudocatalase, Dr. Schallreuter added.

Current vitiligo treatments, including psoralens plus ultraviolet A radiation and steroids, very infrequently reach a significant efficacy rate, she noted.

Previous studies have indicated high levels of oxidative stress and low levels of epidermal catalase in the skin of patients with vitiligo. Pseudocatalase prevents oxidative stress in vitiliginous skin, she explained.

Dr. Schallreuter and her colleagues obtained punch biopsies from the involved and uninvolved skin of 18 vitiligo patients who were randomly selected before treatment with pseudocatalase; biopsies also were taken 6 and 12 months after treatment.

Patients applied pseudocatalase cream twice daily and were exposed to the sun or to a narrow band of ultraviolet B radiation twice a week.

Pseudocatalase reduced epidermal hydrogen peroxide in vitiliginous skin within 2 minutes at a rate 15 times faster than natural catalase. It also prevented vacuolation in melanocytes and keratinocytes and increased the number of functioning melanocytes in the involved epidermis, she said.

Hailed by some as the cure for vitiligo, Dr. Schallreuter takes a more realistic view. "Pseudocatalase will be a substitutional therapy, not a cure."

Pseudocatalase also may have applications in other skin disorders, she said. For example, in one patient with xeroderma pigmentosum, it significantly reduced de novo actinic keratoses, basal cell carcinomas, and squamous cell carcinomas when applied topically over the entire body over a period of a year.

Pseudocatalase is available from:
Med Specialties Pharmacy
www.Pseudocatalase.com
Yorba Linda, Ca 92886


This page was "borrowed" with permission from
www.vitiligosupport.org. We here at Amjo strongly recommend that you become a member of the www.vitiligosupport.org family.

 
Parent Page

Patients applied pseudocatalase cream twice daily and were exposed to the sun or to a narrow band of ultraviolet B radiation twice a week. Pseudocatalase is available online at <Click Here>

 
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